Helmholtz Zentrum Muenchen (HMGU)
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Location : Neuherberg / Germany |
| Leader : Klaus MAYER | |
| Website : www.helmholtz-muenchen.de/en |
Competences:
The MIPS plant research group has pioneered bioinformatics assisted plant genome analysis and has gained an international standing in this field. The group has been strongly involved in the Arabidopsis genome project and has made important contributions to the deciphering of the maize genome. Ongoing contributions are currently made to the EU funded and internationally executed Medicago genome project and the analysis of the first tomato chromosome. The group is furthermore involved in the analysis of the Sorghum and the Brachypodium genomes. The group’s expertise and resources circumvent generic and modular database systems, a generic pipeline for genome annotation in complex plant genomes, tools for the exploitation of plant EST data, for studying regulatory mechanisms in plants as well as to decipher the regulatory control elements in plants.
Role: GSF GmbH leads WP5 and will implement analytical and database systems for analysis and communication of data obtained in the project. An integrative Triticeae genomics platform that provides integration of cytogenetic, genetic and physical map data and a database and visualisation system for a multispecies comparative and integrative platform will be developed.
Staff members’ profile:
The research group headed by Dr. Klaus Mayer is among the internationally most reputed groups in plant genome oriented bioinformatics and has been highly influential in shaping the field by important and widely recognized contributions and analysis on almost all currently studied plant genomes (Arabidopsis, rice, maize, Medicago, tomato). Klaus Mayers scientific interest is directed towards different levels of applied plant genome oriented bioinformatics. Beside the exhaustive and detailed analysis of plant genomic sequences, allocation of plant genomics information infrastructure and databases, the development of methods and the analysis and discovery of new features and functional interrelations constitute the different working areas. Within EU funded consortia Klaus Mayer is coordinating the bioinformatics analysis of the Medicago genome sequencing and is contributing to the tomato genome sequencing efforts.
References:
- Manuel Spannagl, Octave Noubibou, Dirk Haase, Li Yang, Heidrun Gundlach, Kathrin Klee, Georg Haberer, Heiko Schoof and Klaus F. X. Mayer, MIPSPlantsDB – Plant database resource for integrative and comparative plant genome research, Nucleic Acids Research, 35 (Database issue), D834-D840(2007)
- Georg Haberer, Michael Mader, Peter Kosarev Manuel Spannagl, Li Yang and Klaus F.X. Mayer, Genome scale cis element detection through analysis of correlative expression modules and sequence conservation between Arabidopsis thaliana and Brassica oleracea, Plant Physiology, 142, (2006)
- Rémy Bruggmann, Arvind K. Bharti, Heidrun Gundlach, Jinsheng Lai, Ana C. Pontaroli, Georg Haberer, Galina Fuks, Charles Du, Fusheng Wei, Sarah Young, Christina Raymond, Matt C. Estep, Renyi Liu, Jeffrey L. Bennetzen, Agnes P. Chan, Pablo D. Rabinowicz, John Quackenbush, W. Brad Barbazuk, Rod A. Wing, Steve Rounsley, Bruce Birren, Chad Nusbaum, Klaus F.X. Mayer, and Joachim Messing, Uneven Chromosome Contraction and Expansion in the Maize Genome, Genome Research, 16 (10), 1241-1251 (2006)
- Georg Haberer, Sarah Young, Arvind Bharti, Heidrun Gundlach, Christina Raymond, Galina Fuks, Ed Butler, Rod Wing, Steve Rounsley, Chad Nussbaum, Bruce Birren Klaus Mayer and Joachim Messing, Structure and Architecture of the Maize Genome., Plant Physiology, 139, 1612-1624 (2005)
- Heiko Schoof, Manuel Spannagl, Li Yang, Rebecca Ernst, Heidrun Gundlach, Dirk Haase, Georg Haberer and Klaus F. X. Mayer, MIPS plant genome resurces: A framework for integrative and comparative analyses, Plant Physiology, 138, 1301-1309 (2005)
- Joachim Messing, Arvind K. Bharti, Wojciech M. Karlowski, Heidrun Gundlach, Hye Ran Kim, Yeisoo Yu, Fusheng Wei, Galina Fuks, Cari Soderlund, Klaus F.X. Mayer, Rod A. Wing, Map-based Analysis of Sequence Composition and Genome Organization of Maize. Proc. Natl. Acad. Sci. USA, 101, 14349-14359 (2004)
- The Arabidopsis Genome Initiative [Genome Sequencing Groups; Genome Analysis Group: Klaus Mayer, Owen White et al.; Contributing Authors], Sequence and analysis of the flowering plant Arabidopsis thaliana., Nature 408, 796-815 (2000)
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This project is supported by the European Commission under the 7th Framework Programme
for Research and Technological Development